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Am. J. Trop. Med. Hyg., 41(5), 1989, pp. 504-511
Copyright © 1989 by The American Society of Tropical Medicine and Hygiene

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Immunological Effects of HIV-1 Infection on the Humoral Response to Malaria in an African Population

Fred Wabwire-Mangen, Clive J. Shiff, David Vlahov, Richard Kline, David Serwadda, Nelson K. Sewankambo, Roy D. Mugerwa AND Thomas C. Quinn
Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland; Johns Hopkins University, School of Medicine, Division of Infectious Diseases, Baltimore, Maryland; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; and Makerere Medical School, Kampala, Uganda

We conducted a cross-sectional study to determine the serological response to malaria in an HIV-1 infected population and in a control population in a region of high malaria transmission. The study group consisted of 66 hospitalized patients with clinical acquired immunodeficiency syndrome (AIDS) and 70 trauma patients without clinical AIDS (controls). Mean optical densities of antibody produced against RESA-4, RESA-8, RESA-11, (PNAN)5 and (NAAG)5 synthetic peptides of Plasmodium falciparum were compared between HIV-1 seropositive and HIV-1 seronegative patients using non-parametric statistics. HIV-1 seropositive patients with clinical AIDS had significantly less antibody to the synthetic P. falciparum ring stage peptide, RESA-8 (P = 0.001), than a comparable group of seronegative patients. Antibody levels were also low for the other ring stage peptides, RESA-4 (P = 0.024) and RESA-11 (P = 0.024). Although not statistically significant, antibody levels among the HIV-1 seropositive trauma patients were higher than among the HIV-1 seronegative trauma patients. During HIV-1 infection, a polyclonal B cell activation may occur as noted in the HIV-1 seropositive trauma patients, but with increased immunosuppression in advanced clinical AIDS, B cell stimulation appears to be diminished. This results in decreased production of malaria antibody.




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E. G. Dembo, V. Mwapasa, J. Montgomery, A. G. Craig, K. A. Porter, S. R. Meshnick, M. E. Molyneux, and S. J. Rogerson
Impact of Human Immunodeficiency Virus Infection in Pregnant Women on Variant-Specific Immunity to Malaria
Clin. Vaccine Immunol., April 1, 2008; 15(4): 617 - 621.
[Abstract] [Full Text] [PDF]


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Copyright © 1989 by the American Society of Tropical Medicine and Hygiene.