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Am. J. Trop. Med. Hyg., 41(4), 1989, pp. 460-466
Copyright © 1989 by The American Society of Tropical Medicine and Hygiene

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The Status of Ivermectin in the Treatment of Human Onchocerciasis

Hugh R. Taylor AND Bruce M. Greene
Dana Center for Preventive Ophthalmology of The Wilmer Institute, Johns Hopkins University, Baltimore, Maryland; and Case Western Reserve University and University Hospitals, Cleveland, Ohio

Ivermectin is a macrocyclic lactone that has widespread antiparasitic activity. Numerous clinical trials have shown that ivermectin is safe and effective in the treatment of human infection with Onchocerca volvulus. Although it is rapidly microfilaricidal, it does not cause a severe reaction, as is seen with diethylcarbamazine treatment. The drug temporarily interrupts production of microfilaria but has no known long-lasting effects on the adult worms. In patients with onchocerciasis, a single oral dose of ivermectin (150 µg/kg) repeated once a year leads to a marked reduction in skin microfilaria counts and ocular involvement. At this dose, ivermectin causes minimal side effects and is sufficiently free of severe reactions to be used on a mass scale. It promises to revolutionize the treatment of onchocerciasis.




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K. L. WINTHROP, R. PROANO, O. OLIVA, B. ARANA, C. MENDOZA, A. DOMINGUEZ, J. AMANN, G. PUNKOSDY, C. BLANCO, R. KLEIN, et al.
THE RELIABILITY OF ANTERIOR SEGMENT LESIONS AS INDICATORS OF ONCHOCERCAL EYE DISEASE IN GUATEMALA
Am J Trop Med Hyg, December 1, 2006; 75(6): 1058 - 1062.
[Abstract] [Full Text] [PDF]

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 ScienceHome page
H. Taylor, M Pacque, B Munoz, and B. Greene
Impact of mass treatment of onchocerciasis with ivermectin on the transmission of infection
Science, October 5, 1990; 250(4977): 116 - 118.
[Abstract] [PDF]


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Copyright © 1989 by the American Society of Tropical Medicine and Hygiene.