AJTMH ASTMH Job Mart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 41(2), 1989, pp. 189-197
Copyright © 1989 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pons, H. A.
Right arrow Articles by Stadecker, M. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pons, H. A.
Right arrow Articles by Stadecker, M. J.

Resistance to Reinfection in Experimental Murine Schistosomiasis: Role of Porto-Hepatic Hemodynamics

Hector A. Pons, James S. Morgan, Martha L. Hutchinson, Marcos Rojkind, Roberto J. Groszmann AND Miguel J. Stadecker
Tufts University School of Medicine, Boston, Massachusetts; Veterans Administration Medical Center and Yale University School of Medicine, West Haven, Connecticut; and Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York

Experiments were conducted to evaluate critically, and independently of the immune system, the possible role of hemodynamic mechanisms in resistance to schistosomal reinfection. The effects of a challenge schistosomal infection were compared in groups of mice which were either previously infected with schistosomiasis, vaccinated with irradiated cercariae, or underwent partial portal vein ligation for the induction of portal hypertension and porto-systemic shunting. Following infection with 60 cercariae, the appearance of portal hypertension preceded by {approx} 2 weeks the development of porto-systemic shunting, which reached maximal values 11 weeks postinfection. Such a primary infection conferred on C3H mice an estimated 90% protection to a 2nd infection, measured by the reduction of worm burden. Worm burdens were also reduced in vaccinated and ligated animals as compared to normal controls. The protection amounted to 30% and 56%, respectively, in the C3H strain and 63% and 75–85%, respectively, in the C57Bl/6 strain. Reduction in worm burden in the ligated animals is believed to be due to the extrahepatic porto-systemic vascular shunts. Hemodynamic as well as immunological factors may account for the resistance to reinfection observed in chronic murine schistosomiasis.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
Y. Iwakiri, G. Cadelina, W. C. Sessa, and R. J. Groszmann
Mice with targeted deletion of eNOS develop hyperdynamic circulation associated with portal hypertension
Am J Physiol Gastrointest Liver Physiol, November 1, 2002; 283(5): G1074 - G1081.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1989 by the American Society of Tropical Medicine and Hygiene.