AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 41(2), 1989, pp. 161-168
Copyright © 1989 by The American Society of Tropical Medicine and Hygiene

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Plasmodium Falciparum Associated Placental Pathology: A Light and Electron Microscopic and Immunohistologic Study

Minoru Yamada, Richard Steketee, Carlos Abramowsky, Masatoshi Kida, Jack Wirima, David Heymann, John Rabbege, Joel Breman AND Masamichi Aikawa
Case Western Reserve University, Cleveland, Ohio; Centers for Disease Control. Atlanta, Georgia; and Ministry of Health, Malawi

Pathological changes were studied by light and electron microscopy on term placentas collected in Malawi from 20 P. falciparum infected women (11 primiparas and 9 multiparas). One placenta from an uninfected term primipara and 4 from multiparas were studied as controls. Changes included the presence of parasitized erythrocytes and malarial pigment particles in the intervillous space, excessive syncytial knotting, chronic basal villitis, malarial pigment deposits in the trophoblasts, trophoblastic damage with focal necrosis, partial loss of microvilli, and thickening of the trophoblastic basement membrane. Infected erythrocytes were not seen in the fetal circulation. Severity appeared to correlate with the level of maternal and placental parasitemias, regardless of infant birth weight or placental weight. Differences in the severity of pathological changes between primiparas and multiparas could not be demonstrated. Immunohistochemistry revealed that 45% of the placentas stained strongly for IgG and 15% stained for C3 and for P. falciparum antigens in the trophoblastic cytoplasm and basement membrane.




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A. Muthusamy, R. N. Achur, M. Valiyaveettil, J. J. Botti, D. W. Taylor, R. F. Leke, and D. C. Gowda
Chondroitin Sulfate Proteoglycan but Not Hyaluronic Acid Is the Receptor for the Adherence of Plasmodium falciparum-Infected Erythrocytes in Human Placenta, and Infected Red Blood Cell Adherence Up-Regulates the Receptor Expression
Am. J. Pathol., June 1, 2007; 170(6): 1989 - 2000.
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Copyright © 1989 by the American Society of Tropical Medicine and Hygiene.