AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 40(6), 1989, pp. 579-584
Copyright © 1989 by The American Society of Tropical Medicine and Hygiene

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Cross-Reacting Antigens to Pc96, a Protective Antigen of Plasmodium chabaudi, in P. falciparum, P. vivax, and P. cynomolgi

Chingchai Wanidworanun, John W. Barnwell, Hideyuki Nagasawa, Masamichi Aikawa AND Hannah L. Shear
New York University Medical Center, New York, New York, and Institute of Pathology, Case Western Reserve University, Cleveland, Ohio

Mice can be partially protected against Plasmodium chabaudi by immunization with the antigen Pc96, isolated from the erythrocyte membranes of infected mice. We used a Pc96 specific monoclonal antibody to identify antigens which cross-react with Pc96 in P. falciparum, P. vivax, and P. cynomolgi. The cross-reactive molecules are antigens of Mr 155,000 in P. falciparum, Mr 220,000 in P. vivax, and Mr 200,000 in P. cynomolgi. They are located in the surface membranes of infected erythrocytes. Pc96 is characterized by immunoelectron microscopy and epitope mapping.






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Copyright © 1989 by the American Society of Tropical Medicine and Hygiene.