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Granuloma Formation in Schistosoma japonicum Infected Nude Mice: the Effects of Reconstitution with L3T4⁺ or Lyt2⁺ Splenic Cells

The role of L3T4⁺ and Lyt2⁺ lymphocytes in the formation and modulation of granulomas around Schistosoma japonicum eggs was examined in athymic mice. Nude C57BL/6 mice infected with S. japonicum miracidia were compared to nude mice given normal spleen cells depleted of L3T4⁺ or Lyt2⁺ cells prior to infection and to intact mice. Nude mice formed small granulomas that were poor in eosinophils and connective tissue. Nude mice reconstituted with cells enriched for L3T4⁺ or Lyt2⁺ cells formed granulomas similar in size to those in intact mice, but granulomas in mice given Lyt2⁺ cells contained few eosinophils and had significantly less collagen than did granulomas in mice given L3T4⁺ cells. The same was true at 10 weeks. Mice reconstituted with null cells were examined at 7 weeks and formed granulomas similar to those in mice given Lyt2⁺ cells. By 10 weeks after infection, granulomas had decreased to the same minute size in all groups of mice. Fibrosis increased at weeks 7–10 in all groups of mice.

Accepted for publication July 31, 1988.