HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Deelder, A. M. Articles by Polderman, A. M. Search for Related Content PubMed PubMed Citation Articles by Deelder, A. M. Articles by Polderman, A. M.

Quantitative Determination of Circulating Antigens in Human Schistosomiasis Mansoni using an Indirect Hemagglutination Assay

André M. Deelder, Niels De Jonge, Yvonne E. Fillié, Dieuwke Kornelis, Daan Helaha, Zhong-Li Qian^*, Paul De Caluwé AND Anton M. Polderman

Laboratory of Parasitology, Medical Faculty, State University of Leiden, Wassenaarseweg 62, Leiden, The Netherlands
^* Department of Parasitology, Shanghai Second Medical University, Shanghai, People's Republic of China
Service Médical, Société Minière et Industrielle du Kivu, Kalima, Zaire

In serum and urine specimens collected from a group of Schistosoma mansoni infected individuals from Makundju, Zaire, the schistosome circulating anodic antigen (CAA) and the circulating cathodic antigen (CCA) were quantitatively determined using an indirect hemagglutination reaction with sheep erythrocytes sensitized with mouse IgM monoclonal antibodies directed against these circulating antigens. Levels of CAA in serum (up to 5 ng/ml) and CCA in serum and urine (up to 50 ng/ml) were strongly correlated with egg excretion and with each other. No correlation was found between egg excretion and antibody levels against the circulating antigens. Antigen was detectable only in patients excreting > 500 eggs per gram of feces.

Accepted for publication July 23, 1987.