HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Taylor, R. M. Articles by Frothingham, T. E. Search for Related Content PubMed PubMed Citation Articles by Taylor, R. M. Articles by Frothingham, T. E.

Sindbis Virus: A Newly Recognized Arthropod-Transmitted Virus¹

1. Studies on Sindbis virus, a newly recognized member of the arthropod-transmitted viruses, are described; these include data on its immunological characteristics, distribution in the Nile Valley, vertebrate host range, and transmissibility by arthropods.

2. The virus has been isolated from mosquitoes during three successive summers, and once from a juvenile hooded crow (Corvus corone sardonius).

3. It has been placed by Casals and Brown (1954) in Group A of the arthropod-transmitted viruses, but is distinguishable from other members of this group by the neutralization test.

4. Its particle size, estimated by gradacol membrane filtration, is between 40 and 48 mu.

5. On initial passages by brain-to-brain transfer it is fatal to infant mice but not to adult mice.

6. It is highly fatal to embryonated hens' eggs and is markedly cytopathogenic to outgrowths of fibroblastic cells in chick embryo tissue cultures.

7. Experimentally it is easily transmitted by Culex mosquitoes (Culex pipiens L. and Culex univittatus Theobald), and Ornithodoros savignyi (Audouin) ticks are infectible by parenteral puncture and will subsequently transmit the infection by feeding upon infant mice.

8. Antibody surveys imply a) a wide vertebrate host range including man, domestic quadrupeds, birds, and domestic fowl, and b) frequent human infection (27 per cent), particularly in the age group of 15 years and over (34 per cent), in the Nile Delta, and less frequent human infection (12 per cent) in the Southern Sudan.

9. No information is available on the symptomatology of natural infections.

¹ This study was conducted under the auspices of the Ministry of Public Health of the Egyptian Government and the U. S. Naval Medical Research Unit No. 3 (NAMRU-3), with aid from The Rockefeller Foundation, and latterly from the Office of Naval Research through a contract administered by the University of Chicago.

The opinions or assertions contained herein are the private ones of the authors and are not to be construed as official or reflecting the views of the Navy Department or the Naval Service at large.

² Present address: The Rockefeller Foundation Virus Laboratories. 66th Street & York Ave., New York 21, New York.

³ Present address: Children's Hospital, Boston, Massachusetts.

This article has been cited by other articles:

				D. J. Pierro, E. L. Powers, and K. E. Olson Genetic determinants of Sindbis virus strain TR339 affecting midgut infection in the mosquito Aedes aegypti J. Gen. Virol., May 1, 2007; 88(5): 1545 - 1554. [Abstract] [Full Text] [PDF]

				H. NI, N. E. YUN, M. A. ZACKS, S. C. WEAVER, R. B. TESH, A. P. T. DA ROSA, A. M. POWERS, I. FROLOV, and S. PAESSLER RECOMBINANT ALPHAVIRUSES ARE SAFE AND USEFUL SEROLOGICAL DIAGNOSTIC TOOLS Am J Trop Med Hyg, April 1, 2007; 76(4): 774 - 781. [Abstract] [Full Text] [PDF]

				C Xiong, R Levis, P Shen, S Schlesinger, C. Rice, and H. Huang Sindbis virus: an efficient, broad host range vector for gene expression in animal cells Science, March 3, 1989; 243(4895): 1188 - 1191. [Abstract] [PDF]