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The Effect of Oxysteroids on Trypanosoma Cruzi Infection in Mice

Compound S does not depress the resistance of d b a mice to Trypanosoma cruzi, but cortisone and hydrocortisone induce acute fatal trypanosomiasis. Whereas cortisone gives rise to marked peripheral parasitemia, and only 11.1% of mice survive more than two weeks, hydrocortisone induces a mild but transient peripheral parasitemia with 45 % of mice surviving longer than two weeks. Compound S does not protect mice infected with T. cruzi against cortisone if the latter is administered within five days, but there is a partial and increasing protection against cortisone as the interval between administration of Compound S and cortisone is increased (9 to 26 days).