AJTMH ASTMH Job Mart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 4(4), 1955, pp. 705-711
Copyright © 1955 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Packchanian, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Packchanian, A.

Chemotherapy of African Sleeping Sickness. I. Chemotherapy of Experimental Trypanosoma Gambiense Infection in Mice (Mus Musculus) with Nitrofurazone1

Ardzroony Packchanian
Department of Bacteriology and Parasitology and Laboratory of Microbiology, School of Medicine, The University of Texas, Galveston

The virulence of a strain of Trypanosoma gambiense was exalted to such an extent that it produced acute infection in mice (Mus musculus) which invariably terminated fatally within a week. Acute, always fatal Tr. gambiense infection in white mice was cured with adequate doses of nitrofurazone. A total dose of 50 mg./kg. body weight had only a suppressive effect. However, with an increase in total dosage from 150 mg./kg. to 450 mg./kg., divided into small doses and administered daily, cures were obtained in from 22 to 100 per cent of the cases. The curative results were approximately the same whether the drug was administered intraperitoneally or orally.

Preliminary screening tests revealed also three other nitrofuran compounds effective against Tr. gambiense infection in mice. Nitrofuran No. 65 (5-nitro-2-furfurylidene amino biuret) produced a suppressive effect, while nitrofurans No. 60 (5-nitro-2-furaldehyde thiosemicarbazone) and No. 67 [5-nitro-2-furaldehyde 2-(2-hydroxyethyl semicarbazone)] were curative.

It is recommended that human cases of African trypanosomiasis, refractory to other known trypanocides, be treated orally with nitrofurazone.


1 Part of this study was supported by a contract between the University of Texas and the Office of Naval Research, U. S. Navy.

The writer is indebted to James Smith and J. E. Stevens of the Laboratory of Microbiology for their aid in this study, and to Dr. E. L. Daily of the Eaton Laboratories for a supply of 89 different nitrofuran compounds.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1955 by the American Society of Tropical Medicine and Hygiene.