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Experimental Inoculation of Bacteria-Free Trichomonas Vaginalis into Human Vaginae and its Effect on the Glycogen Content of Vaginal Epithelia

Nine volunteers received bacteria-free Trichomonas vaginalis into the vagina. Seven of them became infected and developed vaginitis of varying intensity. The amount of glycogen (GI) in the vaginal mucosa varied inversely with the number of the organisms in the vaginal discharge, with minimal concentrations of 2 per cent in glycogen content in epithelial cells at the period of maximum population of trichomonads. It is suggested that vigorous consumption of glycogen by Trichomonas vaginalis facilitates the invasion of bacteria into vagina, with resulting vaginitis.