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Am. J. Trop. Med. Hyg., 4(2), 1955, pp. 217-220
Copyright © 1955 by The American Society of Tropical Medicine and Hygiene

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Toxicity Studies of Pyrimethamine (Daraprim1)

Raymond J. Dern, Ernest Beutler, John Arnold, Allan Lorincz, Matthew Block AND Alf S. Alving
Army Malaria Research Unit, Department of Medicine, University of Chicago, Chicago, Illinois

The administration of pyrimethamine (Daraprim) to 81 men in doses of 25 mg. weekly for 6 months failed to produce toxic effects. In 133 other men, who received the drug as malaria therapy on various schedules, no toxic effects which could be unequivocably attributed to pyrimethamine were observed.


1 This work was supported (in part) by the Research and Development Division, Office of the Surgeon General, Department of the Army, under Contract No. DA-49-007-MD-20 with the Department of Medicine, University of Chicago, Chicago, Illinois.

The investigations reported in this paper would not have been possible except for the cooperation of the inmates and the administrative staff of Stateville Penitentiary.






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Copyright © 1955 by the American Society of Tropical Medicine and Hygiene.