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Review of Investigations in Malaria Chemotherapy (U. S. A.) 1946 to 1954¹

The history of research in malaria chemotherapy in the period 1946 to 1954 was centered largely about investigations stimulated by the Research Grants program of the Public Health Service and later carried to the point of field evaluation under guidance of the National Research Council with active financial support and participation of the Armed Services. There were independent excursions in malaria chemotherapy by various pharmaceutical establishments and by university workers, but with the possible exception of the work associated with the discovery of pyrimethamine, none of these efforts was of great weight nor did they produce results which now command attention either at the practical or theoretical level.

The major research efforts in malaria chemotherapy of the post World War II era can be divided into two main periods. The first, 1946 to 1950, involved clarification, consolidation, and extension of leads developed during the program of malaria research directed by the Office of Scientific Research and Development (OSRD) during World War II.

¹ This paper was prepared at the request of the Division of Medical Sciences, National Research Council, and approved by its Panel on Malaria.