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Am. J. Trop. Med. Hyg., 4(2), 1955, pp. 198-207
Copyright © 1955 by The American Society of Tropical Medicine and Hygiene

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Recent Advances in Our Knowledge of Dengue and Sandfly Fever1,2,

Albert B. Sabin
The Children's Hospital Research Foundation, University of Cincinnati College of Medicine, Cincinnati, Ohio

The chief advances in our knowledge of dengue during the past 2 years are in the demonstration that: 1) paralytogenic activity in intracerebrally inoculated monkeys of viruses submitted to prolonged passages in mice is due to the appearance of a new mutant and not to increased concentration of virus; 2) the Type 2, New Guinea "C" strain, after 18 passages in mice, has lost its virulence for man but not its immunogenic capacity; 3) early passage levels of both immunologic types of mouse-adapted virus possess sufficient "genetic stability" as regards propagation without appearance of the paralytogenic mutant, that fixed seed lots can be used for the preparation of a bivalent vaccine for human use; 4) specific hemagglutinins are associated with the 2 types of dengue virus and can be the basis of a simple in vitro serologic test for rapid diagnosis and epidemiologic survey.

The chief advances in our knowledge of sandfly fever during the past 2 years stem from the demonstration that mouse pathogenic mutants can be developed by propagation in newborn mice. The immunologically distinct Sicilian and Naples strains were both adapted to mice to a point where they are equally virulent for newborn and adult mice by the intracerebral route. Tests performed with the mouse-adapted Sicilian strain in human beings revealed that it lost its virulence but not its immunogenic capacity. These mouse-adapted strains provide new tools for diagnosis, epidemiologic survey and prevention of sandfly fever.


1 The Nineteenth Annual Charles Franklin Craig Lecture, delivered before the American Society of Tropical Medicine and Hygiene, November 5, 1954.


2 The studies summarized in this lecture were sponsored by the Commission on Virus and Rickettsial Diseases, Armed Forces Epidemiological Board, and supported partly by the office of The Surgeon General, Department of the Army and partly by funds provided under Contract AF 18(600)548 with the USAF School of Aviation Medicine, Randolph Field, Texas.




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Copyright © 1955 by the American Society of Tropical Medicine and Hygiene.