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Am. J. Trop. Med. Hyg., 39(6), 1988, pp. 582-585
Copyright © 1988 by The American Society of Tropical Medicine and Hygiene

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Hepatitis B Virus Infection and Hepatocellular Carcinoma: Correlation between IgM Antibody to Hepatitis B Core Antigen, Hepatitis B e Antigen, and Hepatitis B DNA

Maria H. Sjogren*, Geoffrey M. Dusheiko, Michael C. Kew AND Ernest Song
* Department of Virus Diseases, Walter Reed Army Institute of Research, Washington, DC
Department of Medicine, Witwatersrand University Medical School of Johannesburg and Hillbrow Hospitals, Johannesburg, South Africa

Sera from 102 black patients with primary hepatocellular carcinoma (PHC) and hepatitis B surface antigenemia were tested for immunoglobulin M antibody against hepatitis B core (IgM anti-HBc), hepatitis B e antigen (HBeAg), and hepatitis B viral (HBV) DNA. Their prevalences were compared to those of a control group of 124 age and sex matched black HBV carriers without tumor. IgM anti-HBc was present in 68.6%, HBeAg in 32.3%, and HBV-DNA in 26.7% of the patients. In the control population, IgM anti-HBc was present in 45%, HBeAg was detected in 3.2%, and HBV-DNA in 25.8%. We conclude that IgM anti-HBc is present appreciably more often than either HBeAg or HBV-DNA in patients with PHC. HBeAg or IgM anti-HBc in serum of HBsAg positive carriers may predict an added risk of PHC development in South African blacks.

Accepted for publication May 21, 1988.






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Copyright © 1988 by the American Society of Tropical Medicine and Hygiene.