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Interaction of Malaysian Sera with Plasmodium Vivax Sporozoite Antigen

Melinda Lee, Don R. Davis, W. Ripley Ballou^*, Gail Folena-Wasserman AND George E. Lewis

Malaria Research Group, United States Army Medical Research Unit, Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia
^* Department of Immunology, Walter Reed Army Institute of Research, Washington, DC 20307
Department of Protein Biochemistry, SK&F Laboratories, Swedeland, Pennsylvania

A seroepidemiologic survey of Plasmodium vivax and Plasmodium falciparum transmission was conducted in 94 Orang Asli children and adults. The prevalence of malaria was 46% in this population, and infections due to P. vivax and P. falciparum occurred with equal frequency. Multi-species infection was common, particularly in children <10 years of age. Circumsporozoite (CS) antibodies to P. vivax were detected by ELISA, using the recombinant protein NS1₈₁ V20, in sera from 53–95% of all subjects in this study. The specificity of reactivity to NS1₈₁ V20 was confirmed by immunofluorescence using air-dried sporozoites. CS antibodies to P. falciparum were present in <50% of the population <30 years of age. These data support further testing of this protein as a candidate vivax vaccine.

Accepted for publication May 29, 1988.