AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 39(5), 1988, pp. 511-518
Copyright © 1988 by The American Society of Tropical Medicine and Hygiene

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Failure of a Dengue 1 Sub-Unit Vaccine to Protect Mice against a Lethal Dengue Virus Infection

John. G. Aaskov*,{dagger},, Linda Williams{dagger}, Jennifer Fletcher{dagger} AND Robin Hay{dagger}
* Department of Medical Laboratory Science, Queensland Institute of Technology, Brisbane,
and{dagger} Queensland Institute of Medical Research, Brisbane, Australia

Mice immunized with DEN-1 pre-matrix protein produced antibody which reacted with dengue virus infected cells and intact virions but failed to neutralize virus in vitro or in vivo. Newborn mice passively immunized with anti-DEN-1 pre-matrix antibody also failed to survive intracerebral infection with 100 LD50 of any dengue virus serotype.

Accepted for publication May 4, 1988.






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Copyright © 1988 by the American Society of Tropical Medicine and Hygiene.