AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 39(3), 1988, pp. 250-255
Copyright © 1988 by The American Society of Tropical Medicine and Hygiene

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The Synergistic Action of Pyrazolopyrimidines and Pentavalent Antimony against Leishmania donovani and L. braziliensis

Samuel Martinez*, Douglas L. Looker, Randolph L. Berens AND J. Joseph Marr
* Department of Medicine, University of Cauca, Popoyan, Colombia, and Division of Infectious Diseases, University of Colorado Health Sciences Center, 4200 E. 9th Avenue, Denver, Colorado 80262

Pyrazolopyrimidines, particularly allopurinol, allopurinol riboside, and other purine analogues, show promise as experimental therapeutic compounds for the treatment of leishmaniasis. The combination of these agents with pentostam may produce an improved therapeutic effect. We report here on strong synergistic activity between pyrazolopyrimidines and pentavalent antimonials in a human macrophage tissue culture system infected with Leishmania donovani and L. braziliensis.

Accepted for publication March 8, 1988.






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Copyright © 1988 by the American Society of Tropical Medicine and Hygiene.