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Antibody Responses to Malarial Antigens in the Wopkaimin Population of the Star Mountains, Papua New Guinea

William E. Collins^*, Jacqueline Cattani, John A. Lourie, Tukutau Taufa, William Anderson, Jimmie C. Skinner^*, Peggy S. Stanfill^* AND Alan Y. Huong^*

^* Malaria Branch, Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia
Departments of Human Biology and Community Medicine, University of Papua New Guinea
Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea

Antibody responses to malarial antigens were determined in 614 serum samples collected from the Wopkaimin population of the Star Mountains of Papua New Guinea. In point prevalence surveys made in 1982–1983, 33.7% of the persons examined were infected with Plasmodium falciparum, P. vivax, or P. malariae. Of these, 72.9% were infected with P. falciparum. In a standard fluorescent antibody test, highest level responses were to P. falciparum, followed by P. malariae, P. vivax, and P. ovale. A strong correlation was found between results of the fluorescent antibody tests and those obtained in an enzymelinked immunosorbent assay using P. falciparum antigens. The failure of immune responses to eliminate these species of Plasmodium in this highly isolated population is discussed.

Accepted for publication March 24, 1988.

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