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Am. J. Trop. Med. Hyg., 39(2), 1988, pp. 202-205
Copyright © 1988 by The American Society of Tropical Medicine and Hygiene

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Cross-Neutralization Tests among Cache Valley Virus Isolates Revealing the Existence of Multiple Subtypes

Charles H. Calisher, Marta S. Sabattini*, Thomas P. Monath AND Katherine L. Wolff
Division of Vector-Borne Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, P.O. Box 2087, Fort Collins, Colorado 80522-2087
* Institute of Virology "Dr. J. M. Vanella," Faculty of Medical Sciences, University of Cordoba, Estafeta 32, 5000 Cordoba, Argentina

Maguari virus has been classified as a subtype of Cache Valley virus. Seven Bunyamwera serogroup viruses (including prototypes Cache Valley and Maguari viruses), 4 viruses shown in previous tests as close antigenic relatives of Maguari or Cache Valley viruses, and Xingu virus were cross-tested by serum dilution-plaque reduction neutralization. All viruses were distinguishable from prototypes Cache Valley and Maguari viruses. The close antigenic relationships of the Cache Valley-like viruses demonstrate that multiple subtypes of Cache Valley virus exist and suggest that such antigenic variation is a phenotypic expression of considerable genetic diversity.

Accepted for publication January 12, 1988.






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Copyright © 1988 by the American Society of Tropical Medicine and Hygiene.