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Hyperreactive Malarial Splenomegaly in Venezuela

A cross-sectional seroepidemiological survey seeking hyperreactive malarial splenomegaly was carried out in isolated Yanomami hamlets in Amazonas Territory in Venezuela. All 110 inhabitants > 1 year of age were evaluated clinically and 98 were studied immunologically.

The spleen index for individuals > 10 years of age was 44%. Only 3 patients had Plasmodium spp. on thick blood smears. All had serological evidence of infection with Plasmodium falciparum and P. vivax. Twenty-three patients were considered to show hyperreactive malarial splenomegaly.

Clinical manifestations of the syndrome did not differ from those described in other parts of the world.

Accepted for publication September 24, 1987.