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Aerosol Transmission of Hantaan and Related Viruses to Laboratory Rats

Edwin O. Nuzum^*, Cynthia A. Rossi^*, Edward H. Stephenson AND James W. LeDuc^*

^* Disease Assessment
Airborne Diseases Divisions, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21701-5011

Hantaan, Seoul, and Puumala viruses were transmitted to 12–16-week-old female Wistar Rattus norvegicus by inhalation. The rodent infectious dose for each virus by intramuscular inoculation and by inhalation was determined, as was the infectious dose for Vero E-6 cells by direct plaque assay.

Accepted for publication December 31, 1987.

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