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Large Scale Production of the Vertebrate Infective Stage (L₃) of Onchocerca Volvulus (Filarioidea: Onchocercidae)

Eddie W. Cupp^*, Michael J. Bernardo^*, Anthony E. Kiszewski^*, Milan Trpis AND Hugh R. Taylor

^* Department of Entomology, Comstock Hall, Cornell University, Ithaca, New York 14853-0999
The Johns Hopkins University, School of Hygiene and Public Health, 615 N. Wolfe Street, Baltimore, Maryland 21205
The Wilmer Institute, The Johns Hopkins Hospital, 600 N. Wolfe Street, Baltimore, Maryland 21205

Laboratory-derived Simulium yahense and S. sanctipauli females were used to produce large numbers of Onchocerca volvulus infective stage larvae (L₃) for use in assessing the possible chemoprophylactic potential of ivermectin in the chimpanzee model. Engorgement rates and subsequent post-prandial survival were correlated with the time at which adult flies were offered a carbohydrate source following emergence and the age of flies that fed on microfiladermic volunteers.