AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 38(3), 1988, pp. 582-588
Copyright © 1988 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hii, J. L. K.
Right arrow Articles by Dennis, D. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hii, J. L. K.
Right arrow Articles by Dennis, D. T.

The Effect of Diethylcarbamazine Citrate on Incidence and Recovery Rates of Brugia Malayi Microfilaremia in Sabah, Malaysia

Jeffrey Lu King Hii*, Spencer Kin Ping Kan*, Sidhu Singh Parmar*, Mechiel Kin Chung Chan*, Joon Wah Mak{dagger}, Patricia Kim Chool Lim{dagger}, Teong Wah Lim{dagger} AND David T. Dennis{ddagger}
* Department of Medical Services, 88814 Kota Kinabalu, Sabah, Malaysia
{dagger} Institute for Medical Research, Jalan Pahang, 50468 Kuala Lumpur, Malaysia
{ddagger} State Department of Health and Welfare, New Hampshire 03301

Mass drug administration via 3 modes of delivery reduced the incidence and prevalence rates and intensity of Brugia malayi infection in 3 rural villages in the Bengkoka Peninsula, Sabah, in 1982–1983. A dosage of 6 mg diethylcarbamazine citrate (DEC-C)/kg body weight was administered either daily or weekly (total of 6 doses, 36 mg/kg body weight), and impact on B. malayi cases were comparable in the 3 villages. A total of 384 people participated in the DEC-C regimens, and all pregnant women and children under 2 years were excluded from the study. Bekessy's method of estimation of incidence and recovery rates was applied to data on B. malayi microfilaremia before drug administration. Treatment with DEC-C by any of the 3 modes of delivery drastically reduced the number of episodes of patent microfilaremia, incidence and prevalence, and median microfilarial density. Reduction was sustained for at least 18 to 24 months after treatment.

Accepted for publication September 24, 1987.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1988 by the American Society of Tropical Medicine and Hygiene.