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Am. J. Trop. Med. Hyg., 38(3), 1988, pp. 474-476
Copyright © 1988 by The American Society of Tropical Medicine and Hygiene

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In Vitro Synthesis of Immunoglobulins in Cutaneous Leishmaniasis

Rudy F. M. Lai A Fat*, Jimmy C. Chan Pin Jin*, Robby G. H. M. Lieuw A Joe{dagger}, Martina M. C. Diesselhoff-den Dulk{dagger} AND Ralph van Furth{dagger}
* Department of Dermatology, University Hospital, Paramaribo, Suriname
{dagger} Veterinary Laboratory of the Ministry of Agriculture, Animal Husbandry, and Fisheries, Paramaribo, Suriname
{dagger} Department of Infectious Diseases, University Hospital, Leiden, The Netherlands

In an in vitro study, IgG was synthesized in large amounts by tissue from cutaneous leishmaniasis lesions. IgA and IgM were produced in the minority of the cultures in distinct and small amounts, respectively. Synthesis of complement (C3 and C4) could not be detected, but lysozyme was produced sporadically. The significance of these findings is discussed.

Accepted for publication November 9, 1987.






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Copyright © 1988 by the American Society of Tropical Medicine and Hygiene.