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Oltipraz-Induced Reduction in Schistosomal Glucose Utilization Rates

The rate of phosphorylation of 2-deoxyglucose (2DG) was determined by sequential pulsing of schistosomes (male and female Schistosoma mansoni) with [³H- and ¹⁴C]-2-deoxy-D-glucose. The relative phosphorylation rate of 2-[³H]-2DG to 1-[¹⁴C]-D-glucose (i.e., the phosphorylation coefficient) was also measured in male and female schistosomes. Even though 2DG is taken up more rapidly than glucose, it is phosphorylated at a much slower rate in S. mansoni. Mated schistosomes phosphorylate 2DG and glucose at a greater rate than do unmated worms. In contrast, the phosphorylation coefficient is greater in separated than mated schistosomes. In schistosomes exposed to oltipraz for short time periods (6 min, at a concentration of 10 µg/ml) glucose utilization rates were significantly reduced in (both mated and separated) female S. mansoni and by a similar magnitude (not significant) in males.

Accepted for publication August 4, 1987.