AJTMH Tropical Medicine and Hygiene News
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 38(1), 1988, pp. 42-46
Copyright © 1988 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mendis, K. N.
Right arrow Articles by David, P. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mendis, K. N.
Right arrow Articles by David, P. H.
Right arrowPubmed/NCBI databases
Medline Plus Health Information
*Malaria

Diversity of Plasmodium Vivax-Induced Antigens on the Surface of Infected Human Erythrocytes

Kamini N. Mendis*, Ranjan I. Ihalamulla* AND Peter H. David{dagger}
* Department of Parasitology, Faculty of Medicine, University of Colombo, Kynsey Road, Colombo 8, Sri Lanka
{dagger} Unite d' Immunoparasitologie, Institute Pasteur, 25 Rue du Dr Roux, Paris 75724, France

Antigens were demonstrated on the surface of Plasmodium vivax schizont-infected erythrocytes by an indirect immunofluorescence test using fresh unfixed infected erythrocytes from acute vivax malaria patients. Surface immunofluorescence was used to show that sera of P. vivax-infected individuals contain antibodies directed against these surface antigens. Thirteen different isolates were screened for reactivity of surface antigens with a panel of 8 heterologous human immune sera and an immune rabbit serum. Surface immunofluorescence was detected in several isolates with some but not all the human sera, and not all sera reacted with the "positive" isolates. These results indicate a high degree of polymorphism of the surface antigens of different P. vivax isolates. Sera from patients who had suffered multiple malaria attacks and the immune rabbit serum (which was raised by immunizing with 7 different isolates) recognized surface antigens on more isolates than sera from patients who had experienced only one attack of malaria, indicating that repeated exposure to the disease confers immunity against a spectrum of variants of a polymorphic malarial antigen(s) prevalent in nature.

Accepted for publication June 23, 1987.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1988 by the American Society of Tropical Medicine and Hygiene.