AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 38(1), 1988, pp. 15-18
Copyright © 1988 by The American Society of Tropical Medicine and Hygiene

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Analysis of Dose-Response Curves for the In Vitro Susceptibility of Plasmodium Falciparum to Antimalarials using a Pocket Computer

G. E. Childs AND L. Pang
U.S. Army Medical Component, Armed Forces Research Institute of the Medical Sciences, Rajvithi Road, Bangkok, Thailand

A small pocket computer, Sharp PC-1500, was programmed to analyze the dose-response curves generated by the in vitro assay of antimalarials against field isolates of Plasmodium falciparum. Using nonlinear regression the analysis provided an estimate of the 50% inhibitory concentration with 95% confidence limits and a graph of the data points and regression function line. The pocket computer with the nonlinear regression program offers a powerful, portable, and inexpensive data analysis system suitable for field use.

Accepted for publication July 6, 1987.







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Copyright © 1988 by the American Society of Tropical Medicine and Hygiene.