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Antimalarial Activity of a Riboflavin Analog against Plasmodium vinckei in Vivo and Plasmodium falciparum in Vitro

William B. Cowden^*, Geoffrey A. Butcher, Nicholas H. Hunt^*, Ian A. Clark AND Fumio Yoneda

^* Department of Experimental Pathology, John Curtin School of Medical Research, P.O. Box 334, Canberra ACT 2601, Australia
Zoology Department, The Faculties, Australian National University, Canberra, Australia
Faculty of Pharmaceutical Sciences, Kyoto University, Sakyo-Ku, Kyoto, Japan

The riboflavin analog 10-(4'-chlorophenyl)-3-methylflavin was found to have significant activity against Plasmodium vinckei vinckei when administered orally and parenterally; it was active against P. falciparum in culture. It inhibited mouse erythrocyte glutathione reductase in a dose-dependent manner. When administered orally, 5-deazariboflavin was not active in vivo although it has been shown to have activity against P. falciparum in vitro.

Accepted for publication May 11, 1987.