HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Collins, W. E. Articles by Campbell, C. C. Search for Related Content PubMed PubMed Citation Articles by Collins, W. E. Articles by Campbell, C. C.

Infection of Chimpanzees with Nigerian I/CDC Strain of Plasmodium ovale

William E. Collins^*, Marguerite Pappaioanou^*, Harold M. McClure, R. Brent Swenson, Elizabeth Strobert, Jimmie C. Skinner^*, Valerie Filipski^*, Peggy S. Stanfill^*, Frank H. Collins^* AND Carlos C. Campbell^*

^* Malaria Branch, Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Atlanta, Georgia 30333
Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia 30322

Seven splenectomized chimpanzees were infected with the Nigerian I/CDC strain of Plasmodium ovale. Two of the animals had no history of previous malarial infection whereas three had been infected with P. vivax, one with P. malariae, and one with P. vivax and P. malariae. The two animals with no previous malarial experience had maximum parasitemias of 88,700 and 127,000 per mm³ while the other animals had maximum parasitemias ranging from 10,100 to 60,600 per mm³. Anopheles freeborni, An. dirus, An. stephensi, and An. gambiae were readily infected via membrane feeding on heparinized blood obtained from these chimpanzees during the ascending phases of their primary attacks. The parasitemias in the chimpanzees with previous malarial experience were transient.

Accepted for publication May 22, 1987.