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Albendazole Therapy in Alveolar Hydatid Disease: A Report of Favorable Results in Two Patients after Short-Term Therapy

J. F. Wilson^*, R. L. Rausch, B. J. McMahon^*, P. M. Schantz, D. E. Trujillo^* AND M. A. O'Gorman^*

^* Departments of Surgery and Medicine, Alaska Native Medical Center, Alaska Area Native Health Service, Indian Health Service, P.O. Box 7-741, Anchorage, Alaska 99510,
Division of Animal Medicine, School of Medicine, University of Washington, Seattle, Washington 98195,
and Helminthic Diseases Branch, Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Atlanta, Georgia 30333

Albendazole was administered preoperatively to two patients with active alveolar hydatid disease for 58 and 84 days. Vesicles of larval Echinococcus multilocularis obtained from surgical tissues were inoculated into red-backed voles for in vivo testing viability. No proliferation of the larval cestode had occurred when the animals were dissected three months post-inoculation. These findings suggest that short-term therapy with albendazole was effective in killing the larval cestode in these two cases. Albendazole was found to be hepatotoxic but resulting transaminase abnormalities have been reversible. Close monitoring of liver function and hematology is essential in patients under albendazole therapy.

Accepted for publication January 26, 1987.

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