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Human and Primate Malarial Sera Inhibit Fc Receptor-Mediated Phagocytosis

Hannah Lustig Shear^*, James Brown, Jurg Gysin, James B. Jensen AND Savanat Tharavanij^¶

^* Department of Medical and Molecular Parasitology, New York University Medical Center, New York, New York 10016,
Medical Research Council Laboratories, The Gambia, West Africa,
Institut Pasteur, B.P. 304, Cayenne, 97300, French Guyana,
Department of Microbiology and Public Health, Michigan State University, East Lansing, Michigan 48824,
^¶ Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok 4, Thailand

Sera obtained from humans in P. falciparum-endemic regions and from P. vivax-infected Saimiri sciureus were assayed for their ability to inhibit Fc receptor-mediated phagocytosis. Some sera of humans exposed to P. falciparum from The Gambia, Sudan, and Thailand inhibited ingestion via the Fc receptor by normal human monocytes. In addition, sera from infected monkeys and a high molecular weight fraction of infected monkey serum inhibited ingestion of EIgG by normal monkey spleen macrophages. Generally, inhibition was correlated with higher parasitemia and higher IFA titers.

Accepted for publication September 16, 1986.