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In Vitro and in Vivo Adaptation of the Geneve/SGE-1 Strain of Plasmodium falciparum to Growth in a Squirrel Monkey (Saimiri sciureus) Model

Carol Jo Fajfar-Whetstone^*, William E. Collins AND Miodrag Ristic^*

^* Department of Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, Illinois 61801
and Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30333

Human erythrocytic culture-adapted parasites of the Geneve/SGE-1 strain of Plasmodium falciparum were successfully adapted to grow in an in vitro culture system containing squirrel monkey erythrocytes and serum. These monkey culture-adapted organisms were then used to produce a patent infection in a splenectomized squirrel monkey. Fresh infected blood from this animal was introduced into another splenectomized monkey and was subsequently serially passed through seven intact squirrel monkeys. High level parasitemias (> 10%) were obtained in the animals from the last two passes following inoculation of moderate numbers of parasites. It is anticipated that this squirrel monkey-adapted Geneve/SGE-1 strain of P. falciparum will continue to produce high level parasitemias in intact Bolivian Saimiri, and consequently will be suitable for challenge of these monkeys.

Accepted for publication September 10, 1986.