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Inhibition of Polyamine Biosynthesis by -Difluoromethylornithine in African Trypanosomes and Pneumocystis carinii as a Basis of Chemotherapy: Biochemical and Clinical Aspects^*

Peter P. McCann^**, Cyrus J. Bacchi, Allen B. Clarkson, Jr., Chairmen, Philippe Bey^**, Albert Sjoerdsma^**, Paul J. Schecter^**, Peter D. Walzer AND John L. R. Barlow, Discussants^**

^** Merrell Dow Research Institute, Cincinnati, Ohio 45215,
Haskins Laboratories and Department of Biology, Pace University, New York, New York 10038,
Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, New York 10010,
and Cincinnati Veterans Administration Medical Center and Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267

The symposium provided dramatic evidence of the value of the use of polyamine inhibition via -difluoromethylornithine (DFMO, eflornithine) for advances in chemotherapy of Trypanosoma brucei gambiense sleeping sickness and Pneumocystis carinii pneumonia in acquired immune deficiency syndrome (AIDS) and also for further understanding the metabolic importance of the ubiquitous polyamines in these organisms.

Accepted for publication July 6, 1986.

^* Summary of symposium presented at the joint meeting of the American Society of Tropical Medicine and Hygiene and the American Society of Tropical Veterinary Medicine, 3–7 November 1985 in Miami, Florida.