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Antioxidants do not Prevent the In Vitro Induction of Plasmodium Falciparum Crisis Forms by Human Malaria-Immune, TB or Rabbit TNF Serum

Cultured Plasmodium falciparum was retarded in intraerythrocytic development by serum from malaria-immune adults, by human TB serum, and by rabbit tumor necrosis serum. Neither the potency nor efficacy of any of these sera was altered by a variety of antioxidants or oxygen-free radial scavengers, including ascorbate, -tocopherol, BHT, cystine or cyteine, glutathione, histidine, phenylalanine, tryptophan, tyrosine, superoxide dismutase, catalase (or combination of the two enzymes), or by reducing the ambient O₂ tension to 1%. It is thus unlikely that the antiparasitic activity of these inhibitory sera can be attributed to oxidative mechanisms.

Accepted for publication February 16, 1986.