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Experimental Infection and Protection of Lambs with a Minute Plaque Variant of Rift Valley Fever Virus

The injection of a single dose containing 5 x 10³ plaque forming units (PFU) of a minute plaque variant of Rift Valley fever virus (RVFV) into two susceptible lambs resulted in no detectable viremia, pyrexia or clinical signs of disease. Immunization with the minute plaque variant induced neutralizing antibody as early as seven days post-inoculation; however, no complement fixing antibodies were detected. Lambs immunized in this manner were protected when challenged with an infectious dose containing 1 x 10³ PFU of wild type RVFV. These data indicate that the minute plaque variant may hold promise as a candidate live virus animal vaccine.

Accepted for publication December 16, 1985.

This article has been cited by other articles:

				B. H. Bird, C. G. Albarino, A. L. Hartman, B. R. Erickson, T. G. Ksiazek, and S. T. Nichol Rift Valley Fever Virus Lacking the NSs and NSm Genes Is Highly Attenuated, Confers Protective Immunity from Virulent Virus Challenge, and Allows for Differential Identification of Infected and Vaccinated Animals J. Virol., March 15, 2008; 82(6): 2681 - 2691. [Abstract] [Full Text] [PDF]