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Thrombocytopenia in Leptospirosis: The Absence of Evidence for Disseminated Intravascular Coagulation

Charles N. Edwards^*, George D. Nicholson^**, Trevor A. Hassell^*, Christopher O. R. Everard AND Joy Callender^**

^* Department of Medicine, Queen Elizabeth Hospital
^** Faculty of Medical Sciences, University of the West Indies, Barbados
Medical Research Council/Barbados Government Leptospira Laboratory, Collymore Rock, St. Michael, Barbados, West Indies

In a prospective study of human leptospirosis, thrombocytopenia was demonstrated in 54% of 24 cases. The only additional laboratory evidence suggestive of disseminated intravascular coagulation lay in a mild elevation of fibrinogen degradation products, but this occurred with equal frequency in nonthrombocytopenic patients. There is therefore no causal relationship between disseminated intravascular coagulation and the thrombocytopenia of human leptospirosis.

Accepted for publication October 23, 1985.

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