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Am. J. Trop. Med. Hyg., 35(2), 1986, pp. 350-351
Copyright © 1986 by The American Society of Tropical Medicine and Hygiene

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Marrow Aplasia During High Dose Mebendazole Treatment

Fernando Fernández-Bañares, Ferran González-Huix, Xavier Xiol, Isabel Catalá, Josefa Miró, Natividad López AND Luis Casais
Departments of Gastroenterology, Pathology and Hematology, Hospital de Bellvitge "Princeps d'Espanya," L'Hospitalet de Llobregat, Barcelona, Spain

A patient with chronic liver disease was treated with large doses of mebendazole for a hepatic hydatid cyst. Eighteen days after beginning treatment he developed marrow aplasia which reverted to normal after the drug was stopped. This is the sixth patient described as developing marrow aplasia when treated with large doses of mebendazole. We suggest that the aplasia is related to the dose of the drug, and that the patient's chronic liver disease was an important factor in its genesis. Patients treated with large doses of mebendazole should have their blood counts monitored during treatment.

Accepted for publication October 28, 1985.






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Copyright © 1986 by the American Society of Tropical Medicine and Hygiene.