AJTMH HINARI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 35(2), 1986, pp. 323-329
Copyright © 1986 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Doehring, E.
Right arrow Articles by Feldmeier, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Doehring, E.
Right arrow Articles by Feldmeier, H.

The Effect of Metrifonate in Mixed Schistosoma Haematobium and Schistosoma Mansoni Infections in Humans

Ekkehard Doehring*, Ulrich Poggensee AND Hermann Feldmeier
* Department of Pediatric Nephrology and Metabolic Disorders, Kinderklinik, Medizinische Hochschule, 3 Hannover 61, FRG, and Department of Immunodiagnosis and Immunoparasitology, Landesinstitut für Tropenmedizin, 1 Berlin 19, FRG

In order to examine the effect of metrifonate, 156 patients with mixed Schistosoma haematobium and mansoni infection were randomly divided into three groups and treated with metrifonate (twice 10 mg/kg body weight), oxamniquine (60 mg/kg) and praziquantel (40 mg/kg), respectively. The output of S. haematobium and S. mansoni ova were quantitatively assessed in urine and stool. Application of metrifonate resulted in a similar reduction of S. haematobium and S. mansoni eggs in the urine, whereas no effect on egg excretion was observed in the stool irrespective of the parasite species. In contrast, oxamniquine influenced the output of S. mansoni ova in stool and urine, but showed no effect on S. haematobium egg excretion. Praziquantel was equally effective against both parasite species. The chemotherapeutic effects were not of transient nature since the number of ova of both parasite species remained unchanged five months after treatment. The results clearly indicate that metrifonate acted exclusively on adult worms located in the perivesical plexus irrespective of the parasite species.

Accepted for publication September 21, 1985.




This article has been cited by other articles:


Home page
 J Wildl DisHome page
W. J. Loughry, R. W. Truman, C. M. McDonough, M.-K. Tilak, S. Garnier, and F. Delsuc
IS LEPROSY SPREADING AMONG NINE-BANDED ARMADILLOS IN THE SOUTHEASTERN UNITED STATES?
J. Wildl. Dis., January 1, 2009; 45(1): 144 - 152.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
C. H. King and A. A. F. Mahmoud
Drugs Five Years Later: Praziquantel
Ann Intern Med, February 15, 1989; 110(4): 290 - 296.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1986 by the American Society of Tropical Medicine and Hygiene.