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Am. J. Trop. Med. Hyg., 35(1), 1986, pp. 86-93
Copyright © 1986 by The American Society of Tropical Medicine and Hygiene

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Specific and Sensitive Immunological Diagnosis of Chagas' Disease by Competitive Antibody Enzyme Immunoassay Using a Trypanosoma cruzi-Specific Monoclonal Antibody

J. L. Lemesre*, D. Afchain*, O. Orozco*, M. Loyens*, F. S. Breniere**, P. Desjeux**, Y. Carlier{dagger}, U. Martin{ddagger}, J. A. Nogueira-Queiroz§, D. Le Ray AND A. Capron*
* Centre d'Immunologie et de Biologie Parasitaire, Institut Pasteur, 15 rue Camille Guérin, 59019 Lille Cédex, France ,
** Instituto Boliviano de Biologia de Altura, La Paz, Bolivia ,
{dagger} Laboratoire de Parasitologie, Faculté de Médecine, ULB, Bruxelles, Belgium ,
{ddagger} Centro de Investigaciones Sobre Endemias Nacionales, Santa Fe, Argentina ,
§ Nucleo de Medicina Tropical, Fortaleza, Brazil
and Institut de Médecine Tropicale, Anvers, Belgium

Coexistence of Chagas' disease with leishmaniasis and T. rangeli infection in endemic areas and cross-reactivity between corresponding etiological agents can confuse the immunodiagnosis of Chagas' disease. A discriminative serological test could therefore represent a major advance in specific immunodiagnosis. A competitive antibody enzyme immunoassay against a component 5-enriched preparation, using a T. cruzi species-specific monoclonal antibody has allowed development of a specific serodiagnosis of Chagas' disease with high sensitivity (96.6% in undetermined and chronic phases of infection). This test can differentiate Chagas' disease from other cross-reacting parasitic diseases in areas where concomitant infections are unknown or suspected.

Accepted for publication July 1, 1985.






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Copyright © 1986 by the American Society of Tropical Medicine and Hygiene.