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Am. J. Trop. Med. Hyg., 35(1), 1986, pp. 66-68
Copyright © 1986 by The American Society of Tropical Medicine and Hygiene

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Malaria Transmitted to Humans by Mosquitoes Infected from Cultured Plasmodium falciparum

Jeffrey D. Chulay*, Imogene Schneider*, Thomas M. Cosgriff{dagger}, Stephen L. Hoffman*,{ddagger},, W. Ripley Ballou*, Isabella A. Quakyi§, Richard Carter§, James H. Trosper{ddagger} AND Wayne T. Hockmeyer*
* Walter Reed Army Institute of Research, Washington, DC 20307-5100 ,
{dagger} U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21701 ,
{ddagger} Naval Medical Research Institute, Bethesda, Maryland 20814 ,
and§ Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, Maryland 20205

Malaria was transmitted to six normal human volunteers by mosquitoes infected from cultured gametocytes of Plasmodium falciparum. This method, which offers advantages over other methods of infecting volunteers, will be useful for evaluating the efficacy of human malaria vaccines.

Accepted for publication September 4, 1985.




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Copyright © 1986 by the American Society of Tropical Medicine and Hygiene.