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A Simplified Serological Test for Leprosy Based on a 3,6-di-O-Methylglucose-Containing Synthetic Antigen

The recent advent of synthetic antigens containing the Mycobacterium leprae-specific epitope, 3,6-di-O-methyl-ß-D-glucopyranoside, has allowed the development of simple specific serological tests for leprosy. The incorporation of one such product, 8-carbonyloctylO-[4-O-(3,6-di-O-methyl-ß-D-glucopyranosyl)--L-rhamnopyranoside]-BSA, into a simple "spot" test, diffusion-in-gel enzyme-linked immunosorbent assay (ELISA), allowed an over 90% detection rate of untreated lepromatous leprosy, and the results showed good concordance with conventional ELISA based on the native phenolic glycolipid I.

Accepted for publication July 8, 1985.