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Am. J. Trop. Med. Hyg., 34(6), 1985, pp. 1095-1097
Copyright © 1985 by The American Society of Tropical Medicine and Hygiene

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Adoptive Transfer of Vaccine-Induced Resistance to Leishmania Donovani*

J. C. Jarecki-Black, A. B. Glassman AND E. R. James
Departments of Laboratory Medicine and Ophthalmology, Medical University of South Carolina, Charleston, South Carolina 29425

BALB/c mice were immunized with three subcutaneous injections combining killed parasites and glucan, or were untreated. Spleen cells were transferred to syngeneic recipients. Mice which received 5 x 108 spleen cells from vaccinated donors demonstrated significant protection against Leishmania donovani challenge as compared to untreated mice receiving immune sera, or mice which received untreated spleen cells.

Accepted for publication June 27, 1985.


* In memoriam, Thomas W. Holbrook, 1941–1983.






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Copyright © 1985 by the American Society of Tropical Medicine and Hygiene.