HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Wakeel, E. S. E. Articles by Jensen, J. B. Search for Related Content PubMed PubMed Citation Articles by Wakeel, E. S. E. Articles by Jensen, J. B.

Clindamycin for the Treatment of Falciparum Malaria in Sudan

El Sadiq El Wakeel^*, Mamoun M. A. Homeida^**, Hassan M. Ali, Timothy G. Geary AND James B. Jensen

^* Department of Physiology
^** Department of Medicine
Pharmacology, Faculty of Medicine, University of Khartoum, Khartoum, Sudan
Department of Microbiology and Public Health, Michigan State University, East Lansing, Michigan 48824-1101

Clindamycin, 5 mg/kg twice a day for 5 days, was used to treat falciparum malaria after clinical and parasitological diagnosis at a health station in Faki Hashim, a suburb of Khartoum, Sudan. Twenty out of twenty-six patients enrolled completed the study. Giemsa-stained thick blood films were negative for asexual parasites by day 7 in 17 patients and by day 8 in the remaining 3. All were examined on days 14 or 28; 2 who had initially been cleared by day 6 had asymptomatic low density asexual parasitemia on day 14, which disappeared without treatment by day 28, and 2 others initially cleared by day 5 were similarly positive at day 28. Reinfection in these patients cannot be ruled out.

Of the 6 patients withdrawn from the study, 2 took chloroquine independently, 1 developed vomiting, 1 developed diarrhea, 1 acquired a circumoral maculopapular rash, and 1 had an increasing parasitemia on day 3 and was switched to chloroquine. Generally, the treatment was without toxicity and was well received. Clindamycin proved satisfactory for the treatment of simple cases of falciparum malaria in the field in Africa.

Accepted for publication June 4, 1985.