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In Vivo and in Vitro Effects of Cyclosporin A on Trypanosoma Cruzi^*

R. E. McCabe^**,,, J. S. Remington^**,, AND F. G. Araujo^**

^** Department of Immunology and Infectious Diseases, Research Institute, Palo Alto Medical Foundation, Palo Alto, California 94301
Department of Medicine, Stanford University, Stanford, California 94305

The in vivo and in vitro effects of cyclosporin A on T. cruzi were examined. Mice receiving 150 or 75 mg/kg/day of cyclosporin A and infected with T. cruzi 48 hr later had significantly higher parasitemias and earlier mortality than controls. Mice receiving cyclosporin A after infection had parasitemias similar to controls. Infections with both the reticulotropic Y and the miotropic CL strains of T. cruzi were enhanced by cyclosporin A. The in vitro replication of epimastigotes, but not the intracellular replication of amastigotes, in mouse macrophages was inhibited by 5 µg cyclosporin A/ml. Enhancement of the infection by cyclosporin A was not due to an effect of macrophages since the drug did not prevent development of activated macrophages capable of killing intracellular T. cruzi.

Accepted for publication April 10, 1985.

^* Address reprint requests to: Dr. Jack S. Remington, Research Institute, Palo Alto Medical Foundation, 860 Bryant Street, Palo Alto, California 94301.