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Am. J. Trop. Med. Hyg., 34(3), 1985, pp. 476-483
Copyright © 1985 by The American Society of Tropical Medicine and Hygiene

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Diethylcarbamazine-Mediated Clearance of Brugia pahangi Microfilariae in Immunodeficient Nude Mice

Ann C. Vickery, Jai K. Nayar* AND Mark L. Tamplin
College of Public Health, University of South Florida, Tampa, Florida 33612
* Florida Medical Entomology Laboratory, Institute of Food and Agricultural Sciences, University of Florida, Vero Beach, Florida 32962

Congenitally athymic nude C3H/HeN mice, microfilaremic with Brugia pahangi, were treated with diethylcarbamazine citrate (DEC). A single oral dose (100 mg/Kg body weight) of DEC resulted in the rapid reduction of numbers of circulating microfilariae in nude, thymus-grafted nude and complement-depleted nude mice. Antibodies of the IgM and IgG isotypes were not detected in the serum of microfilaremic nudes or on the microfilarial surface. These results suggest that DEC-mediated clearance of microfilariae from the circulation of nude mice is probably independent of thymus-dependent immunological mechanisms.

Accepted for publication November 13, 1984.






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Copyright © 1985 by the American Society of Tropical Medicine and Hygiene.