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Am. J. Trop. Med. Hyg., 34(3), 1985, pp. 417-418
Copyright © 1985 by The American Society of Tropical Medicine and Hygiene

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Induction and Isolation of Artemisinine-Resistant Mutants of Plasmodium falciparum

Joseph Inselburg
Department of Microbiology, Dartmouth Medical School, Hanover, New Hampshire 03756

Five artemisinine-resistant mutants of Plasmodium falciparum have been isolated from a cloned parent following mutagenic treatment with N-methyl-N'-nitronitrosoguanidine. This observation may influence the strategy of the use of artemisinine or its derivatives. Mutant isolation should prove useful in the study of drug resistance to other antimalarials.







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Copyright © 1985 by the American Society of Tropical Medicine and Hygiene.