AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 34(2), 1985, pp. 216-222
Copyright © 1985 by The American Society of Tropical Medicine and Hygiene

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In Vitro Culture of Two Populations (Dividing and Nondividing) of Exoerythrocytic Parasites of Plasmodium Vivax

Michael R. Hollingdale, William E. Collins, Carlos C. Campbell AND Alan L. Schwartz
Biomedical Research Institute, 12111 Parklawn Drive, Rockville, Maryland 20852, Malaria Branch Centers for Disease Control, Atlanta, Georgia, and Division of Pediatric Hematology Oncology, Dana Farber Cancer Institute, Children's Hospital Medical Center, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115

Plasmodium vivax sporozoites invaded human hepatoma cells and differentiated into 2 types of exoerythrocytic (EE) parasites. One group was composed of actively dividing schizonts, which released merozoites after 9 days of culture. The second group was nondividing and persisted after the primary schizonts disappeared from the culture. EE schizonts progressively lost reactivity to monoclonal antibodies to the surface-protective protein antigen of P. vivax sporozoites, but the persisting parasites remained strongly reactive. In the 2 strains of P. vivax studied, the ratio of schizonts to persisting parasites was approximately equal.

Accepted for publication October 9, 1984.




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J. SATTABONGKOT, N. YIMAMNUAYCHOKE, S. LEELAUDOMLIPI, M. RASAMEESORAJ, R. JENWITHISUK, R. E. COLEMAN, R. UDOMSANGPETCH, L. CUI, and T. G. BREWER
ESTABLISHMENT OF A HUMAN HEPATOCYTE LINE THAT SUPPORTS IN VITRO DEVELOPMENT OF THE EXO-ERYTHROCYTIC STAGES OF THE MALARIA PARASITES PLASMODIUM FALCIPARUM AND P. VIVAX.
Am J Trop Med Hyg, May 1, 2006; 74(5): 708 - 715.
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Copyright © 1985 by the American Society of Tropical Medicine and Hygiene.