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Crossed Immunoelectrophoresis for the Detection of Split Products of the Third Complement Component in Dengue Hemorrhagic Fever

II. In Vitro Activation by Dengue Viral Antigen

Vina Churdboonchart^*, Natth Bhamarapravati AND Sutee Yoksan

^* Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok
Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Bangkok, Thailand

The ability of dengue viral antigen(s) from different sources, and preformed antigen-antibody complexes, to activate the third component of human complement (C3) in vitro was demonstrated by using split products of human C3. Dengue type 2 viral antigen(s) from suckling mouse brain and from infected monocytes activated C3 via the alternative pathway, while preformed soluble dengue-2 antibody complex activated mainly the classical pathway. The implications of this finding for the pathogenesis of dengue hemorrhagic fever are discussed.

Accepted for publication April 6, 1984.