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Association of a Sindbis-Like Virus with Ockelbo Disease in Sweden^*

Bo Niklasson^,,, Ake Espmark, James W. LeDuc, Thomas P. Gargan, Willis A. Ennis, Robert B. Tesh^|| AND Andrew J. Main, Jr.^||

Department of Infectious Diseases, Roslagastull Hospital, S-114 89 Stockholm, Sweden
Department of Virology, National Bacteriological Laboratory, S-105 21 Stockholm, Sweden
U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21701
^|| Yale University School of Medicine, Yale Arbovirus Research Unit, New Haven, Connecticut 06510

An alphavirus isolated from Culiseta mosquitoes has been associated with Ockelbo disease, an exanthema arthralgia syndrome occurring in Sweden. The isolate was made from mosquitoes collected in Edsbyn (central Sweden), an area with considerable Ockelbo disease morbidity. This isolate proved to be indistinguishable from Sindbis virus by complement-fixation and hemagglutination-inhibition tests, and was antigenically related to Sindbis in plaque reduction neutralization tests. Patients with Ockelbo disease developed neutralizing antibodies to the virus in their convalescent sera, suggesting that it is the etiologic agent of the disease.

Accepted for publication May 9, 1984.

^* The views of the authors do not purport to reflect the position of the Department of the Army or the Department of Defense.